Essential
hypertension (EH) is an important worldwide public health issue which
contributes to the burden of heart disease, stroke and kidney failure and
premature mortality and disability. It disproportionately affects populations
in low- and middle-income countries where health systems are weak. EH is a
complex disorder resulting from genetic and environmental factors, as well as
their interactions.
 |
| Essential Hypertension |
Approximately 20-60% of the blood pressure variability in
general population is heritable. Human ADD1 gene, located on chromosome 4p16.3,
encodes one of adducin subunits (α-adducin). Adducin modulates the surface
expression of multiple transporters and ion pumps, and thus regulates cellular
signal transduction and cytolemma ion transport. Human and animal model studies
have found that ADD1 gene is a candidate gene for EH. Read More>>>>>>>>>>>
No comments:
Post a Comment