Several studies have reported the antioxidant,
anti-inflammatory, anticancer, hypocholesterolemic and neuroprotective
properties of tocotrienols in different cell lines, animal models, and in
humans. However, question on the bioavailability of pure tocotrienols remained
unanswered. Therefore, it is important to understand the absorption and bioavailability mechanism of tocotrienols before carrying out investigations into the therapeutic efficacy in humans.
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| Annatto δ-tocotrienol |
The bioavailability of
naturally-occurring tocotrienols differ considerably in their absorption,
therfore therapeutic uses of tocotrienols remain controversial. It was reported
that after feeding rats mixed tocotrienols, the oral bioavailability of
α-tocotrienol was 28% compared to 9% of γ-tocotrienol and δ-tocotrienol.
Tocotrienols in humans were detected in postprandial plasma , and they were
found enriched in triacylglycerol-rich particles, HDL, and LDL after
administration of palm tocotrienol-rich fraction (mixture of 68% tocotrienol +
32% α-tocopherol). Read more>>>>>>>>>>>
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