Association between ADD1 Gly460Trp Polymorphism and Essential Hypertension in Han Chinese

Essential hypertension (EH) is an important worldwide public health issue which contributes to the burden of heart disease, stroke and kidney failure and premature mortality and disability. It disproportionately affects populations in low- and middle-income countries where health systems are weak. EH is a complex disorder resulting from genetic and environmental factors, as well as their interactions. 

 

Essential Hypertension

Approximately 20-60% of the blood pressure variability in general population is heritable. Human ADD1 gene, located on chromosome 4p16.3, encodes one of adducin subunits (α-adducin). Adducin modulates the surface expression of multiple transporters and ion pumps, and thus regulates cellular signal transduction and cytolemma ion transport. Human and animal model studies have found that ADD1 gene is a candidate gene for EH. Read More>>>>>>>>>>>

Role of Dietary Components in Modulating Hypertension

Hypertension is estimated by the Centers for Disease Control and Prevention to affect approximately 30% of adults in theUnited States. It is a significant factor in the pathogenesis of a number of diseases, including obesity, cardiovascular disease, and stroke. 

Hypertension itself can be caused by unhealthy lifestyle habits like alcoholism, drug addiction, smoking, high stress, or obesity, and certain non-modifiable attributes like age, gender, hereditary and genetic constitution, and racial or ethnic disparities. Hypertension to an extent correlates to the prevailing socioeconomic and geographical characteristics of a region, as well as to individual behavioral factors, and can pose a significant public health concern in populations defined by economic hardship, poverty, reduced health care access, low health literacy, and lack of resources due to geographic isolation.  Read more>>>>>>>>>>>>>>

Summative Evaluation of Physician-Pharmacist Collaboration Management

As the health care system adapts to the growing population living with chronic disease there has been a shift in the delivery of primary care towards a team-based, patient-centered model. The benefits of including a pharmacist as amember of a collaborative medical team have been well established. Several systematic reviews and meta analyses have shown the positive impact pharmacists have on improving BP control and managing other cardiovascular risk factors.

The American College of Clinical Pharmacy (ACCP) Ambulatory Care Practice and Research Network (PRN) recently published a paper stressing the importance of pharmacists in the optimization of medication management in the Patient Centered Medical Home (PCMH) and identify pharmacists as an essential component to the success of the PCMH model.  Read more>>>>>>>>>

Renal Denervation, ?Last Resort? or Alternative Therapy?

Arterial hypertension represents one of the main causes of morbidity and mortality among the population with high risk of cerebral strokes, coronary heart disease.It’sarbitrarily defined as “resistant” or “refractory” when recommended blood pressure targets are not achieved, despite changes in lifestyle and treatment with adequate doses of at least three antihypertensive drugs from different classes, including a diuretic.

In a recent clinical study, it’s proved a variable proportion (approximately 5-15%) of the general population of the patients with hypertension in treatment, which refer to the Centres of Excellence for the diagnosis and treatment hypertension, may be considered suffering from resistant hypertension. It‘s evident that 5-15% of patients with hypertension, Whereas 20% of the Western population is suffering from hypertension, is easy to understand the true dimension of the phenomenon. So the choice of treatment, comes to a crossroad. Should we insist with the combination of more than three medications, or choose the path of renal denervation? Read more...............