Immunotherapy in Eosinophilic Granulomatosis with Polyangiitis

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides include granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA, Churg-Strauss). EGPA has distinct features, namely asthma, common rhino-sinusal involvement, hypereosinophilia, tissue infiltration with eosinophils and necrotizing granulomatosis vasculitis. 

 

Polyangiitis

Conventional immunosuppressive therapy and glucocorticoids have been GPA and MPA standard of care for remission induction and maintenance for four decades. This regimen has transformed the outcome from death to a strong likelihood of disease control and temporary remission. However, most patients have recurrent relapses that lead to damage and require repeated treatment. Read More>>>>>>>>