In
full-term newborns, DA routinely closes within one to five days after delivery,
however it’s considered abnormal if it remains patent more than three months after
birth in term infants. The physiological impact and clinical significance of
PDA depend largely on its size and the underlying cardiovascular status of the
patient, so patients with large PDA may develop left-sided volume overload and
pulmonary hypertension at younger ages, leading to diagnosis early in life.
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| Three months after birth in term infants |
If
left untreated, PDA can foster the development of infective endarteritis,
Eisenmenger syndrome, and other conditions, with an annual mortality rate of
1.8%. Ductus closure is clearly indicated for any child or adult who is
symptomatic from significant left-to-right shunting through PDA. Read More>>>>>>>
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