It was previously reported using
meta-analysis that EF in HFPEF is often “greater-than-normal”, that is greater
than the EF in HC of the same age. The physiological basis for this finding is
not clear, though a hypothesis was proposed.
Although remodeling processes in
HFPEF, accounting for morphological changes in the LV, are well established, to
the best of our knowledge investigations comparing how ESV, EDV and EF in HFPEF
differ from their counterparts in HC were not published. Specifically, if EF in
HFPEF (EFHFPEF) is greater than EF in HC (EFHC), the fraction ESV/EDV in HFPEF
must be smaller than that in HC. The magnitude of ESV/EDV may decrease in one
of several forms, yet the expected form is characterized by a decrease in EDV
accompanied by a greater relative decrease in ESV. Read more>>>>>>>>
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