Endothelial-derived microparticles (MPs) are
defined as heterogeneous population of plasma membrane vesicles (diameter
100-1000 nm) produced by apoptotic or activated cells originated from vascular endothelium or circulating endothelial cell.
They are derived from cell
membrane surfaces via blebbing and shedding in physiological (stress, micro environmental
stimulation) and pathological (coagulation/thrombosis, endotoxinemia,
endothelial shear stress, ischemic/hypoxic injury, inflammation, and malignancy)
conditions and are present in low concentrations in normal plasma. Recent
investigations have been shown that endothelial-derived MPs are discussed
powerful paracrine regulators of target cell functions affected cell
differentiation, tissue growth and reparation, vasculogenesis, vasodilation,
inflammation, apoptosis, infection, and malignancy.Read more>>>>>>>>>>
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