Giant-cell
arteritis (GCA) is a granulomatous vasculitis affecting large and medium-sized
vessels with a special tropism for the carotid and vertebral arteries.
Involvement of the superficial temporal artery is very frequent and performance
of temporal artery biopsies is a common diagnostic procedure which facilitates
histopathological confirmation of GCA.
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| Giant-Cell Arteritis |
Temporal artery biopsies are also a
source of valuable tissuenot only for diagnostic purposes but also for
immunopathology studies which have provided important pathogenetic clues. In
fact, the current pathogenesis model is essentially based on the demonstration
of particular cell types and subsets in involved tissue or peripheral blood,
the expression of activation and differentiation markers by these cells and the
production of certain inflammatory molecules in lesions. Read more>>>>>>>>>
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