Rheumatoid
arthritis (RA) is a chronic inflammatory joint pathology which affects almost 1%
of the general population and which is ranked among the top 15% of diseasescausing major disability worldwide. RA shares several pathophysiologicfeatures, genetic predisposition and risk factors with atherosclerosis.
Inflammation is the central pathologic factor in both diseases. The paper
reviews cardiovascular events and their therapy in RA.
Methodology:
A
review must rely on solid data, be objective and deliver the ‘state of the art’
of the argument. The quest is a seemingly endless process. Writing is a
solitary endeavor but data depend on the work of many individuals and
institutions. We started a goal-oriented search in English and German with the
engines BioMedSearch.com, Cardio source, Center Watch, ClinicalTrials.gov,
Cochrane, Google Scholar, Med Watch, Research Gate and PubMed. We settled a
time-window 2000-2016 with key words: RA, arthritis, cardiovascular risk in RA,
and treatment of RA. Our search delivered more than 1 million of references.
The filter was restricted to guidelines and meta-analyses. This search
delivered more than 80,000 references. Using a plagiarism’s software we found
that few centers published more than 60% of the collected references, usually
changing authors’ order, deleting or adding some authors. Many papers present
strikingly similar data.
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