Determination of Ghrelin’s Role in the Pathogenesis of Pregnancy Induced Hypertension

Pregnancy induced hypertension (PIH) is a disease of an unclear etiology that complicates 2-3 % of pregnancies. PIH is a critical cause of perinatal mortality of pregnant women and neonates and a major cause of intrauterine growth retardation and of iatrogenic prematurity. 

PIH is a multiorgan complication; its main causes result from the interaction of the mother’s immunological system with trophoblast antigens. The ethiopathogenesis of pregnancy induced hypertension remains to be elucidated. A crucial risk factor of pregnancy induced hypertension is obesity. Relationships between hypertension and obesity are well documented, ultimately involving excessive retention of sodium by the kidneys, insulin resistance, and chronic stimulation of the sympathetic system, leading to vessel remodelling.  Read more>>>>>>>>>>>>>>