Angiotensin-converting enzyme (ACE) 2 is a
newly recognized ACE homolog within the renin-angiotensin system (RAS) that is
produced and secreted by a variety of cell types. Although ACE2 may act onseveral substrates, it exhibits high catalytic efficiency, specifically for the
hydrolysis of angiotensin (Ang) II to the vasodilator and growth inhibitor
heptapeptide Ang-(1-7).
Previous reports have suggested that Ang-(1-7) exerts
vasodilatory effects through a combination of ACE inhibition and angiotensin
type 1 receptor (AT1R) blockade. Taken together, these studies suggest that the
regulation of Ang-(1-7) production by ACE2 may be an important component of not
only blood pressure control but also vascular remodeling because Ang-(1-7)
opposes the actions of Ang II in both cases. According to this novel concept,
the final functional effects of the RAS may reflect a balance between the
ACE-Ang II-AT1R arm and the ACE2-Ang-(1-7)- Mas receptor arm. Read more>>>>>>>>>>>>>>
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