The
angiogenesis process is vitally important for growth, development and
maintenance of a normal physiological state, playing key roles in essential
processes such as reproduction, wound healing, and development. Despite this,
imbalance of the angiogenic process is observed in a number of disease states.
One key example is seen in cancer, where tumour angiogenesis is essential in
facilitating advanced tumour growth and increased metastatic potential, a
realisation that has led to the development of anti-angiogenic therapies. In
1995, Beckner et al. isolated a 52kDa protein from a human melanoma cell line,
termed Angio-Associated Migratory Cell Protein (AAMP), during a search for
motility associated cell surface proteins.
The cytoplasmic and membrane located
protein contains two immunoglobulin-like domains, a WD40 repeat and a heparin
binding consensus sequence. The WD40 repeat motif is found in a wide range of
proteins with diverse roles in signal transduction, transcriptional activation,
cytoskeletal regulation and cell cycle control. The homology of AAMP with
members of the immune globular super family suggests AAMP may have similar
roles to these members, which include recognition and binding, cell-cell interaction
and cell signalling. Read more>>>>>>>>>>>>>
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