The ex vivo heart perfusion model is a well-accepted
preparation, introduced more than a century ago. Nowadays, it is not so much
used in the study of heart’s physiological principles, but in supplying
corresponding physiological evidence to underlying molecular processes of
ischemia, altered myocardial metabolism, new pharmaceutical agents, etc.,
Although it was named after Oscar Langendorff who demonstrated
its use in the mammalian heart in 1895, the same model was well established by
Elias Cyon in the frog heart as early as 1866 . The chronological reference tothe origin of the method is important not only for historical referencereasons, but also, and particularly so, for highlighting the tremendous efforts
of the early physiologists to develop suitable recording methods in parallel.
Although the continuous pressure monitoring was achieved quite early, almost
simultaneously with the genesis of the model, the morphometric assessment of
the beating heart, by means of volumetric changes, diastolic and systolic
changes, was not possible until much later, during Starling’s era. Read more.............
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